SCHEMBL28095642

SCHEMBL28095642

O=C(CNc1ccccc1Cl)c1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 5/20 0.65
RAB9A P51151 3/20 0.65
KDM4E B2RXH2 2/20 0.65
ALDH1A1 P00352 6/20 0.55
KMT2A Q03164 6/20 0.55
MEN1 O00255 5/20 0.55
HPGD P15428 4/20 0.55
SMN1; SMN2 Q16637 4/20 0.55
MAPT P10636 4/20 0.55
GAA P10253 1/20 0.55
MAPK1 P28482 2/20 0.50
AKR1C3 P42330 1/20 0.50
CYP3A4 P08684 1/20 0.50
ALOX15 P16050 1/20 0.50
CES1 P23141 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
NPC1 O15118 3/20 0.47
GPR55 Q9Y2T6 1/20 0.47
TRPA1 O75762 1/20 0.47
GSK3B P49841 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19707579 0.83 MRGPRX4 (0.58) AGTR1RAB9AKDM4EALDH1A1KMT2A
SCHEMBL158175 0.83 CXCL8 (0.54) RAB9AKDM4EKMT2AMEN1HPGD
SCHEMBL29512015 0.83 CXCL8 (0.54) RAB9AKDM4EKMT2AMEN1HPGD
SCHEMBL21987081 0.83 CA12 (0.60) AGTR1RAB9AKDM4EALDH1A1KMT2A
SCHEMBL11407555 0.82 ALDH1A1 (0.55) AGTR1RAB9AKDM4EALDH1A1KMT2A
Ammonia Solution, Strong SCHEMBL23300490 0.81 CXCL8 (0.53) RAB9AKDM4EKMT2AMEN1HPGD
SCHEMBL28306745 0.81 CXCL8 (0.53) RAB9AKDM4EKMT2AMEN1HPGD
SCHEMBL9768330 0.81 ALPL (0.51) AGTR1RAB9AKDM4EALDH1A1KMT2A
SCHEMBL29620332 0.79 MEN1 (0.50) RAB9AALDH1A1KMT2AMEN1HPGD
SCHEMBL5320792 0.79 RAB9A (0.65) AGTR1RAB9AKDM4EALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106243053-A A kind of triazolylamide ketone antibacterial, synthetic method and application thereof 三峡大学 2016-12-21 CN disclosed