Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | GFER | P55789 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27196390 | 0.81 | MAPT (0.42) | MAPTALDH1A1KDM4EGAAHTT | |
| SCHEMBL27885708 | 0.79 | GSK3A (0.34) | ALDH1A1NPC1POLBRAB9ANPSR1 | |
| SCHEMBL28047941 | 0.79 | LMNA (0.35) | MAPTALDH1A1GFERKDM4EKMT2A | |
| SCHEMBL28047904 | 0.79 | HTR3E (0.35) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL27853541 | 0.79 | MAPT (0.36) | MAPTALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL27885693 | 0.79 | HRH3 (0.37) | — | |
| SCHEMBL666883 | 0.78 | MAPT (0.37) | MAPTKMT2AMEN1NPC1POLB | |
| Hydrochloric Acid SCHEMBL384463 | 0.77 | MAPT (0.36) | MAPTKMT2AMEN1NPC1POLB | |
| SCHEMBL15993007 | 0.76 | POLB (0.43) | MAPTALDH1A1KMT2AGAAHTT | |
| SCHEMBL23884741 | 0.75 | ALDH1A1 (0.49) | ALDH1A1KDM4ENPSR1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105980381-A | Substituted uracils and use thereof | 拜耳医药股份有限公司 | 2016-09-28 | — | — | CN | disclosed |