Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4728793 | 0.85 | OTC (0.40) | OTCPOLBKMT2ATDP1DDAH1 | |
| Arginine SCHEMBL5606089 | 0.85 | ALDH1A1 (0.45) | OTCPOLBKMT2ATDP1DDAH1 | |
| Arginine SCHEMBL4208935 | 0.85 | ALDH1A1 (0.45) | OTCPOLBKMT2ATDP1DDAH1 | |
| Arginine SCHEMBL2485034 | 0.85 | OTC (0.40) | OTCPOLBKMT2ATDP1DDAH1 | |
| Arginine SCHEMBL28911624 | 0.84 | OTC (0.41) | OTCPOLBKMT2ATDP1DDAH1 | |
| Arginine SCHEMBL31315051 | 0.84 | CA2 (0.44) | OTCPOLBKMT2ATDP1DDAH1 | |
| Arginine SCHEMBL28911606 | 0.84 | OTC (0.41) | OTCPOLBKMT2ATDP1DDAH1 | |
| Arginine SCHEMBL1287134 | 0.82 | OTC (0.43) | OTCPOLBKMT2ATDP1DDAH1 | |
| Arginine SCHEMBL12006798 | 0.82 | OTC (0.43) | OTCPOLBKMT2ATDP1DDAH1 | |
| Arginine SCHEMBL29387430 | 0.82 | OTC (0.50) | OTCKMT2ADDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106139156-A | A kind of pharmaceutical composition containing quinoline or its salt | 江苏恒瑞医药股份有限公司 | 2016-11-23 | — | — | CN | disclosed |