Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4208935 | 1.00 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4ECA12CA1 | |
| L-Citrulline SCHEMBL28962982 | 0.90 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Arginine SCHEMBL2485034 | 0.88 | OTC (0.40) | HTTOTCCASRTDP1POLB | |
| Arginine SCHEMBL4728793 | 0.88 | OTC (0.40) | HTTOTCCASRTDP1POLB | |
| Arginine SCHEMBL9644254 | 0.86 | MMP2 (0.41) | KDM4EOTCTDP1POLBKMT2A | |
| Arginine SCHEMBL26914670 | 0.85 | KIF11 (0.46) | OTCTDP1POLBKMT2ADDAH1 | |
| Arginine SCHEMBL28111285 | 0.85 | OTC (0.39) | HTTOTCCASRTDP1POLB | |
| Arginine SCHEMBL1287134 | 0.84 | OTC (0.43) | NAPRTTSHROTCCASRTDP1 | |
| Arginine SCHEMBL12006798 | 0.84 | OTC (0.43) | NAPRTTSHROTCCASRTDP1 | |
| Arginine SCHEMBL28268971 | 0.84 | OTC (0.53) | TSHROTCKMT2ADDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012177433-A1 | TOPICAL COMPOSITIONS FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS | EVOLOGIE LLC (US) | 2012-12-27 | — | — | WO | claimed |
| US-20070042009-A1 | Topical composition for delivery of salicylates | ALPHARX INC (CA) | 2007-02-22 | — | — | US | claimed |
| EP-0936899-A4 | COSMETIC COMPOSITIONS | PROCTER & GAMBLE (US) | 2002-01-02 | — | — | EP | claimed |
| US-6267978-B1 | COSMETIC FOR REGULATION OF THE OILY AND/OR SHINY APPEARANCE OF SKIN | THE PROCTER & GAMBLE COMPANY | 2001-07-31 | — | — | US | claimed |
| US-6143310-A | WATER IN OIL EMULSION CONTAINING AMINO ACID SALT OF SALICYLIC ACID | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-07 | — | — | US | claimed |
| EP-0936899-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1999-08-25 | — | — | EP | claimed |
| CN-1226820-A | Cosmetic composition | PROCTER & GAMBLE (US) | 1999-08-25 | — | — | CN | claimed |
| WO-1998010741-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-19 | — | — | WO | claimed |
| US-12409121-B2 | Formulations and methods for preparing stable cosmetic compositions | Spinart, LLC (US) | 2025-09-09 | — | — | US | disclosed |
| US-20250049674-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST A MEROCYANINE AND A HYDROTROPE | L'OREAL (FR) | 2025-02-13 | — | — | US | disclosed |
| US-20250025393-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND DIPROPYLENE GLYCOL | L'OREAL (FR) | 2025-01-23 | — | — | US | disclosed |
| US-20250009625-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND AT LEAST ONE DIOL COMPRISING FROM 4 TO 7 CARBON ATOMS | L'OREAL (FR) | 2025-01-09 | — | — | US | disclosed |
| US-20240423888-A1 | COSMETIC AND/OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST ONE MEROCYANINE AND AT LEAST ASCORBIC ACID AND/OR A DERIVATIVE THEREOF | L'OREAL (FR) | 2024-12-26 | — | — | US | disclosed |
| CN-118871078-A | Cosmetic or dermatological composition comprising at least a merocyanine and a hydrotrope | 欧莱雅 | 2024-10-29 | — | — | CN | disclosed |
| EP-0936899-A4 | COSMETIC COMPOSITIONS | PROCTER & GAMBLE (US) | 2002-01-02 | — | — | EP | disclosed |
| US-6267978-B1 | COSMETIC FOR REGULATION OF THE OILY AND/OR SHINY APPEARANCE OF SKIN | THE PROCTER & GAMBLE COMPANY | 2001-07-31 | — | — | US | disclosed |
| US-6143310-A | WATER IN OIL EMULSION CONTAINING AMINO ACID SALT OF SALICYLIC ACID | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-07 | — | — | US | disclosed |
| EP-0936899-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1999-08-25 | — | — | EP | disclosed |
| CN-1226820-A | Cosmetic composition | PROCTER & GAMBLE (US) | 1999-08-25 | — | — | CN | disclosed |
| WO-1998010741-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250009625-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND AT LEAST ONE DIOL COMPRISING FROM 4 TO 7 CARBON ATOMS | KRT18, DSC1, ECH1 | ALDH1A1 1066/4885HPGD 2150/4885KDM4E 2121/4885 |
| US-20240423888-A1 | COSMETIC AND/OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST ONE MEROCYANINE AND AT LEAST ASCORBIC ACID AND/OR A DERIVATIVE THEREOF | KRT18, PROC, DSC1 | ALDH1A1 271/4885HPGD 1909/4885KDM4E 1082/4885 |
| US-20250049674-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING AT LEAST A MEROCYANINE AND A HYDROTROPE | NAPRT, NAMPT, NNMT | ALDH1A1 745/4885HPGD 8/4885KDM4E 2686/4885 |
| US-20250025393-A1 | COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND DIPROPYLENE GLYCOL | KRT18, DSC1, DSG1 | ALDH1A1 2036/4885HPGD 1866/4885KDM4E 1786/4885 |
| US-12409121-B2 | Formulations and methods for preparing stable cosmetic compositions | CUTA, ARG1, ODC1 | ALDH1A1 2381/4885HPGD 1418/4885KDM4E 1230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.