Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14638312 | 0.85 | KMT2A (0.41) | KMT2AMEN1NPC1RAB9AGAA | |
| SCHEMBL27969757 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL28000047 | 0.82 | KMT2A (0.42) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL19714744 | 0.79 | HSD11B1 (0.32) | KMT2AMEN1NPC1RAB9AL3MBTL1 | |
| SCHEMBL23199851 | 0.78 | ALDH1A1 (0.47) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL16748755 | 0.78 | ALDH1A1 (0.47) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL16797890 | 0.77 | USP2 (0.37) | SMN1; SMN2POLBALDH1A1KMT2AMEN1 | |
| SCHEMBL16391280 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A | |
| SCHEMBL28000072 | 0.77 | LMNA (0.35) | SMN1; SMN2LMNAPOLBALDH1A1HPGD | |
| SCHEMBL27800388 | 0.77 | LMNA (0.40) | SMN1; SMN2LMNAPOLBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107417684-A | Heterocyclic acryloyloxy amine | 辉瑞公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-106061973-A | Pyrrolo [2,3-D ] pyrimidinyl, pyrrolo [2,3-B ] pyrazinyl and pyrrolo [2,3-D ] pyridylacrylamide | 辉瑞公司 | 2016-10-26 | — | — | CN | disclosed |