Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Adenine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | PI4KA | P42356 | 2/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.37 |
| ▸ | ADCY5 | O95622 | 5/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenine SCHEMBL385841 | 0.88 | PI4KA (0.45) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL14125907 | 0.86 | PI4KA (0.39) | NOTUMPI4KAPI4K2BPI4K2API4KB | |
| Adenine SCHEMBL9621204 | 0.86 | GDA (0.46) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL10790458 | 0.84 | NOTUM (0.34) | APEX1NOTUMPI4KAPI4K2BPI4K2A | |
| Adenine SCHEMBL8110 | 0.84 | PI4KA (0.48) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL3413247 | 0.84 | PI4KA (0.48) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL3416954 | 0.84 | PI4KA (0.48) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL16485900 | 0.83 | PI4KA (0.37) | NOTUMPI4KAPI4K2BPI4K2API4KB | |
| Adenine SCHEMBL16485906 | 0.83 | PI4KA (0.37) | NOTUMPI4KAPI4K2BPI4K2API4KB | |
| Adenine SCHEMBL28140971 | 0.82 | PI4KA (0.41) | PI4KAPI4K2BPI4K2API4KBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146561-A | A kind of synthetic method of tenofovir | 浙江九洲药业股份有限公司 | 2016-11-23 | — | — | CN | claimed |
| CN-107737335-B | Microbubble complexes and methods of use | 通用电气公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-114617868-A | NRF2 activating compounds and uses thereof | 参宿七制药股份有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-108699011-B | NRF2 activating compounds and uses thereof | 参宿七制药股份有限公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-106573901-B | Fumarate analogues and their use in the treatment of autoimmune or inflammatory diseases | 参宿七制药股份有限公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-108699034-B | NRF2 activating compounds and uses thereof | 参宿七制药股份有限公司 | 2020-12-11 | — | — | CN | disclosed |
| CN-112004808-A | Prodrugs of NRF 2-activating compounds and uses thereof | 参宿七制药股份有限公司 | 2020-11-27 | — | — | CN | disclosed |
| CN-106146561-A | A kind of synthetic method of tenofovir | 浙江九洲药业股份有限公司 | 2016-11-23 | — | — | CN | disclosed |