SCHEMBL28113598

SCHEMBL28113598

O=COC(Cc1ccccc1)Cc1cc(O)[nH]n1

nearest known ligand 0.34

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CTSK P43235 4/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
TAAR1 Q96RJ0 1/20 0.34
HCAR2 Q8TDS4 1/20 0.34
CTSL P07711 1/20 0.33
CTSB P07858 1/20 0.33
EPHX1 P07099 1/20 0.33
CYP1A2 P05177 1/20 0.32
SRR Q9GZT4 2/20 0.31
ACP3 P15309 1/20 0.31
SLC1A3 P43003 1/20 0.31
SLC1A2 P43004 1/20 0.31
SLC1A1 P43005 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
PARP1 P09874 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27931420 0.83 RAB9A (0.39) KMT2AEPHX1NPC1RAB9AHSD17B10
SCHEMBL28325986 0.83 HCAR3 (0.34) MEN1KMT2A
SCHEMBL27627222 0.81 HCAR3 (0.30)
SCHEMBL28113126 0.80 CTSK (0.30) CTSKEPHX1
SCHEMBL28113113 0.80 MEN1 (0.35) CTSKMEN1KMT2ATAAR1CTSL
SCHEMBL28113663 0.78 AKR1B1 (0.38)
SCHEMBL28045730 0.78 CTSK (0.37) CTSKMEN1KMT2ATAAR1CTSL
SCHEMBL18085416 0.78 EPHX1 (0.48) CTSKMEN1KMT2ATAAR1CTSL
SCHEMBL28113602 0.76
SCHEMBL28323977 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106304835-A Sgc stimulant 铁木医药有限公司 2017-01-04 CN disclosed