Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 3/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP10 | P09238 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28116823 | 0.93 | CCR8 (0.53) | CCR8KDM4EMEN1KMT2AAPP | |
| SCHEMBL4349231 | 0.88 | KMT2A (0.53) | CCR8KDM4EMEN1KMT2AAPP | |
| SCHEMBL17048461 | 0.87 | CCR8 (0.63) | CCR8KDM4EMEN1KMT2AAPP | |
| SCHEMBL5369178 | 0.85 | L3MBTL1 (0.49) | MEN1KMT2AALDH1A1GAA | |
| SCHEMBL9740346 | 0.81 | L3MBTL1 (0.51) | MEN1KMT2AAPPALDH1A1GAA | |
| SCHEMBL17048430 | 0.80 | CCR8 (0.66) | CCR8KDM4EMEN1KMT2AAPP | |
| SCHEMBL4349232 | 0.80 | MEN1 (0.51) | CCR8KDM4EMEN1KMT2AAPP | |
| SCHEMBL9205385 | 0.80 | L3MBTL1 (0.54) | MEN1KMT2AAPPALDH1A1 | |
| SCHEMBL17099382 | 0.78 | KDM4E (0.50) | CCR8KDM4EMEN1KMT2AAPP | |
| SCHEMBL892946 | 0.77 | HDAC1 (0.51) | MEN1KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106255679-B | As NAThe heterocyclic compound and application thereof of V channel inhibitor | 默克专利有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-106255679-A | As Naheterocyclic compound of V channel inhibitor and application thereof | 默克专利有限公司 | 2016-12-21 | — | — | CN | disclosed |