Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 11/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28119235 | 0.85 | KIF11 (0.48) | KIF11TP53NQO2AKR1C3AKR1C2 | |
| SCHEMBL28118830 | 0.84 | KIF11 (0.47) | KIF11TP53NQO2AKR1C3AKR1C2 | |
| SCHEMBL28119199 | 0.82 | KIF11 (0.50) | KIF11AKR1C3AKR1C2HTTYAP1 | |
| SCHEMBL28118836 | 0.80 | NQO2 (0.47) | NQO2GSK3B | |
| SCHEMBL28119198 | 0.67 | NQO2 (0.47) | NQO2GSK3BHTT | |
| SCHEMBL1921482 | 0.66 | KIF11 (0.70) | KIF11TP53SMN1; SMN2AKR1C3AKR1C2 | |
| SCHEMBL394991 | 0.66 | KIF11 (0.70) | KIF11SMN1; SMN2KDM4EAKR1C3AKR1C2 | |
| SCHEMBL28119197 | 0.66 | NQO2 (0.46) | NQO2GSK3BHTT | |
| SCHEMBL16208518 | 0.66 | KIF11 (1.00) | KIF11AKR1C3AKR1C2 | |
| SCHEMBL4937177 | 0.65 | KIF11 (0.56) | KIF11TP53SMN1; SMN2KDM4EDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | claimed |
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | disclosed |