Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 12/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28119235 | 0.99 | KIF11 (0.48) | KIF11NQO2HTR7AKR1C3AKR1C2 | |
| SCHEMBL28118828 | 0.84 | KIF11 (0.48) | KIF11NQO2AKR1C3AKR1C2HTT | |
| SCHEMBL28119197 | 0.83 | NQO2 (0.46) | NQO2HTR7HTTMEN1MAPT | |
| SCHEMBL28119198 | 0.82 | NQO2 (0.47) | NQO2HTR7HTTMEN1MAPT | |
| SCHEMBL28119199 | 0.81 | KIF11 (0.50) | KIF11AKR1C3AKR1C2RXFP1HTT | |
| SCHEMBL28118909 | 0.81 | NQO2 (0.46) | NQO2HTR7HTTMEN1LMNA | |
| SCHEMBL250063 | 0.69 | GAA (0.54) | HTTMEN1LMNAMAPTKMT2A | |
| SCHEMBL25590656 | 0.67 | LMNA (0.54) | RXFP1SPHK2SPHK1MEN1LMNA | |
| SCHEMBL17817420 | 0.66 | HDAC3 (0.78) | RXFP1MEN1LMNATP53MAPT | |
| SCHEMBL31129776 | 0.66 | HDAC3 (0.78) | RXFP1MEN1LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | claimed |
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | disclosed |