Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | ALPL | P05186 | 2/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | METAP2 | P50579 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2766145 | 0.80 | RAB9A (0.71) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL21775723 | 0.80 | ALPL (0.58) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL15006266 | 0.78 | ALPL (0.51) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL16128887 | 0.77 | ALPL (0.55) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL15908507 | 0.77 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL2360295 | 0.77 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL1160360 | 0.77 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2L3MBTL1ALPL | |
| SCHEMBL792992 | 0.77 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP1A2 | |
| SCHEMBL14097585 | 0.77 | L3MBTL1 (0.92) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP1A2 | |
| SCHEMBL427627 | 0.76 | L3MBTL1 (1.00) | NPC1RAB9ASMN1; SMN2L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103534255-B | Substituted pyrazolopyrimidines as glucocerebrosidase activators | 美国健康及人类服务部 | 2016-12-21 | — | — | CN | claimed |