Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 9/20 | 0.38 |
| ▸ | DNMT3A | Q9Y6K1 | 5/20 | 0.38 |
| ▸ | NSD2 | O96028 | 3/20 | 0.38 |
| ▸ | NSD3 | Q9BZ95 | 3/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 3/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP5 | P51878 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2814053 | 0.88 | SIGMAR1 (0.48) | DNMT3ACASP1CASP5ALDH1A1LMNA | |
| SCHEMBL2809639 | 0.88 | SIGMAR1 (0.48) | DNMT3ACASP1CASP5ALDH1A1LMNA | |
| SCHEMBL2810802 | 0.84 | CASP1 (0.43) | CASP1CASP5ALDH1A1LMNAHTT | |
| SCHEMBL2810498 | 0.83 | DNMT3A (0.44) | DNMT3ACASP1CASP5ALDH1A1LMNA | |
| SCHEMBL2809502 | 0.83 | HTR6 (0.41) | EHMT2NSD2NSD3EHMT1EZH2 | |
| SCHEMBL2813108 | 0.83 | NTSR1 (0.43) | MAPK1HTR1AHTR3A | |
| SCHEMBL2812365 | 0.82 | DRD4 (0.39) | DNMT3ACASP1CASP5ALDH1A1HTT | |
| SCHEMBL537792 | 0.82 | SIGMAR1 (0.46) | CASP1CASP5ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL2810547 | 0.82 | KDM4E (0.43) | CASP1CASP5ACHEUSP2ALDH1A1 | |
| SCHEMBL2809650 | 0.81 | ALDH1A1 (0.40) | ALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343983-B2 | Substituted pyrazolo-pyrimidine compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249110-A1 | SUBSTITUTED PYRAZOLO-PYRIMIDINE COMPOUNDS | DPYD, TYMP, TP53 | EHMT2 3441/4885DNMT3A 2966/4885NSD2 1225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.