Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 11/20 | 0.33 |
| ▸ | GUCY1B1 | Q02153 | 11/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28839896 | 0.83 | NR1H2 (0.34) | ACHECYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL19107669 | 0.83 | THRB (0.47) | GUCY1A1GUCY1B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28128251 | 0.81 | RBP4 (0.43) | CYP3A4CYP2C9CYP2C19ALDH1A1LMNA | |
| SCHEMBL17397709 | 0.79 | NPC1 (0.39) | GUCY1A1GUCY1B1SMN1; SMN2 | |
| SCHEMBL17397533 | 0.77 | GUCY1A1 (0.45) | GUCY1A1GUCY1B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL27842061 | 0.74 | F2 (0.40) | SMN1; SMN2 | |
| SCHEMBL28256778 | 0.73 | NUDT1 (0.38) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL19092639 | 0.72 | GPR119 (0.51) | GUCY1A1GUCY1B1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL28127509 | 0.72 | ABL1 (0.34) | CYP3A4CYP2C9CYP2C19ALDH1A1LMNA | |
| SCHEMBL28256715 | 0.72 | GPR119 (0.37) | ALDH1A1LMNAGPR119SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106470985-A | Indane and indoline derivatives as soluble guanylate cyclase activators and uses thereof | 诺华股份有限公司 | 2017-03-01 | — | — | CN | disclosed |