Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28024448 | 0.85 | OPRL1 (0.36) | NR1H2SLC9A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL28024911 | 0.84 | GPR119 (0.40) | NR1H2SLC9A1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL28128282 | 0.83 | GUCY1A1 (0.33) | SLC9A1CYP2C9CYP2C19CYP3A4KCNH2 | |
| SCHEMBL28128251 | 0.82 | RBP4 (0.43) | SLC9A1CYP2C9CYP2C19CYP3A4KCNH2 | |
| SCHEMBL17397759 | 0.82 | MAPT (0.49) | NR1H2CYP2C9CYP2C19CYP3A4MAPK1 | |
| SCHEMBL27948292 | 0.82 | SLC9A1 (0.48) | SLC9A1CYP2C9CYP2C19CYP3A4KCNH2 | |
| SCHEMBL27842061 | 0.79 | F2 (0.40) | — | |
| SCHEMBL27682015 | 0.79 | RIPK1 (0.39) | CHRNB2CHRNA4 | |
| SCHEMBL17395599 | 0.78 | SLC9A1 (0.38) | SLC9A1CYP2C9CYP2C19CYP3A4HTR1D | |
| SCHEMBL27949194 | 0.78 | HDAC1 (0.38) | CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106470985-A | Indane and indoline derivatives as soluble guanylate cyclase activators and uses thereof | 诺华股份有限公司 | 2017-03-01 | — | — | CN | disclosed |