Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 4/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TAF1 | P21675 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL27875442 | 0.87 | ALDH1A1 (0.38) | KEAP1PDPK1GRM5 | |
| SCHEMBL29361477 | 0.84 | AHR (0.50) | KEAP1PDPK1BACE1AHRMCL1 | |
| SCHEMBL1420318 | 0.84 | AHR (0.50) | KEAP1PDPK1BACE1AHRMCL1 | |
| Trifluoroacetic Acid SCHEMBL29364273 | 0.82 | KEAP1 (0.47) | KEAP1PDPK1BACE1BCHEAHR | |
| Hydrochloric Acid SCHEMBL29363603 | 0.82 | AHR (0.48) | KEAP1PDPK1BACE1AHRMCL1 | |
| Hydrochloric Acid SCHEMBL27757229 | 0.82 | AHR (0.48) | KEAP1PDPK1BACE1AHRMCL1 | |
| Hydrochloric Acid SCHEMBL3826755 | 0.82 | AHR (0.48) | KEAP1PDPK1BACE1AHRMCL1 | |
| Formic Acid SCHEMBL30673625 | 0.81 | KEAP1 (0.45) | KEAP1PDPK1BACE1BCHEAHR | |
| Cadaverine Tartrate SCHEMBL8591738 | 0.75 | PDPK1 (0.79) | KEAP1PDPK1IKBKBCHUKGRM5 | |
| Cadaverine Tartrate SCHEMBL21806572 | 0.73 | AHR (0.63) | KEAP1AHRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106995399-A | A kind of method for preparing Silodosin | 北京天泰恒华医药技术有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-106995399-A | A kind of method for preparing Silodosin | 北京天泰恒华医药技术有限公司 | 2017-08-01 | — | — | CN | disclosed |