Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27950148 | 0.88 | ALDH1A1 (0.49) | ALDH1A1ADORA2ASLC40A1DYRK1AHPGD | |
| Cadaverine Tartrate SCHEMBL28147371 | 0.87 | KEAP1 (0.47) | KEAP1GRM5PDPK1 | |
| Quinoline SCHEMBL27875441 | 0.79 | DYRK1A (0.37) | ALDH1A1ADORA2ADYRK1ALMNANFATC1 | |
| Cadaverine Tartrate SCHEMBL28081412 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HPGDCYP1A2CYP2C9CYP2C19 | |
| Cadaverine Tartrate SCHEMBL5874237 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HPGDCYP1A2CYP2C9CYP2C19 | |
| Cadaverine Tartrate SCHEMBL5874249 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HPGDCYP1A2CYP2C9CYP2C19 | |
| Quinoline SCHEMBL28040754 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KEAP1ADORA2AGRM5PDPK1 | |
| SCHEMBL29361477 | 0.73 | AHR (0.50) | KEAP1PDPK1DYRK1ANFATC1GSK3B | |
| SCHEMBL1420318 | 0.73 | AHR (0.50) | KEAP1PDPK1DYRK1ANFATC1GSK3B | |
| Trifluoroacetic Acid SCHEMBL29364273 | 0.72 | KEAP1 (0.47) | KEAP1GRM5PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102702067-A | Novel intermediate for synthesizing silodosin as well as preparation method and purpose of novel intermediate | BEIJING LIANBEN MEDICAL CHEMICAL TECHNOLOGY CO LTD | 2012-10-03 | — | — | CN | disclosed |