SCHEMBL2814764

SCHEMBL2814764

CCCCCNc1ncnc(N)n1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.50
TLR8 Q9NR97 3/20 0.49
MAPT P10636 1/20 0.44
KCNH3 Q9ULD8 2/20 0.44
DNM2 P50570 5/20 0.43
RAB9A P51151 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
HRH4 Q9H3N8 1/20 0.41
BCL6 P41182 1/20 0.41
S1PR2 O95136 1/20 0.41
LMNA P02545 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
HTT P42858 1/20 0.41
KMT2A Q03164 1/20 0.41
CCNB2 O95067 1/20 0.40
CDK1 P06493 1/20 0.40
CCNB1 P14635 1/20 0.40
CCNB3 Q8WWL7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8618089 0.98 SMN1; SMN2 (0.49) SMN1; SMN2TLR8MAPTKCNH3DNM2
SCHEMBL14354944 0.87 SMN1; SMN2 (0.54) SMN1; SMN2TLR8MAPTRAB9AL3MBTL1
SCHEMBL516082 0.87 KCNH3 (0.54) SMN1; SMN2MAPTKCNH3DNM2HRH4
SCHEMBL8515777 0.85 SMN1; SMN2 (0.44) SMN1; SMN2TLR8MAPTKCNH3DNM2
SCHEMBL19594200 0.80 KCNH3 (0.54) SMN1; SMN2TLR8MAPTKCNH3DNM2
SCHEMBL2851069 0.80 TLR8 (0.53) SMN1; SMN2TLR8MAPTKCNH3DNM2
SCHEMBL14346807 0.80 SMN1; SMN2 (0.57) SMN1; SMN2MAPTRAB9AL3MBTL1BCL6
SCHEMBL11173788 0.79 KCNH3 (0.44) SMN1; SMN2KCNH3DNM2HRH4S1PR2
SCHEMBL2514104 0.79 KMT2A (0.55) SMN1; SMN2KCNH3DNM2HRH4S1PR2
SCHEMBL3301451 0.78 KMT2A (0.53) SMN1; SMN2TLR8MAPTKCNH3DNM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1797868-A1 Cosmetic composition comprising a (thio)urethane/(thio)urea copolymer capable of forming at least 3 hydrogen bonds, and process for cosmetic treatment L'Oréal (FR) 2007-06-20 EP claimed
EP-1797867-A1 Cosmetic or pharmaceutical composition comprising a copolymer containing at least one ionisable group, and cosmetic treatment L'Oréal (FR) 2007-06-20 EP claimed
EP-3548544-B1 AQUEOUS DISPERSION OF POLYALKENE SUPRAMOLECULAR POLYMER AND ITS USE IN COSMETICS OREAL (FR) 2021-07-21 EP disclosed
US-10973751-B2 Hair dyeing process comprising a pigment and an aqueous dispersion of supramolecular polymer L'OREAL (FR) 2021-04-13 US disclosed
US-20200108007-A1 HAIR DYEING PROCESS COMPRISING A PIGMENT AND AN AQUEOUS DISPERSION OF SUPRAMOLECULAR POLYMER L'OREAL (FR) 2020-04-09 US disclosed
EP-3606502-A1 HAIR DYEING PROCESS COMPRISING A PIGMENT AND AN AQUEOUS DISPERSION OF SUPRAMOLECULAR POLYMER L'Oreal (FR) 2020-02-12 EP disclosed
CN-110494122-A Hair colouring methods including pigment and supermolecule polymer water-borne dispersions OREAL 2019-11-22 CN disclosed
EP-3548544-A1 AQUEOUS DISPERSION OF POLYALKENE SUPRAMOLECULAR POLYMER AND ITS USE IN COSMETICS L'OREAL (FR) 2019-10-09 EP disclosed
US-20190274946-A1 AQUEOUS DISPERSION OF POLYALKENE SUPRAMOLECULAR POLYMER AND ITS USE IN COSMETICS L'OREAL (FR) 2019-09-12 US disclosed
CN-110023380-A Aqueous dispersions of polyolefin supramolecular polymers and their use in cosmetics 莱雅公司 2019-07-16 CN disclosed
WO-2018185335-A1 HAIR DYEING PROCESS COMPRISING A PIGMENT AND AN AQUEOUS DISPERSION OF SUPRAMOLECULAR POLYMER L'OREAL (FR) 2018-10-11 WO disclosed
WO-2010146147-A2 COMPOSITION FOR TREATING KERATIN FIBRES COMPRISING A BLOCK COPOLYMER, A SILOXANE RESIN AND A VOLATILE SOLVENT L'OREAL (FR) 2010-12-23 WO disclosed
EP-2263647-A1 Composition for treating keratin fibres, comprising a polyalkene-based supramolecular polymer, a block polymer and a volatile solvent L'Oréal (FR) 2010-12-22 EP disclosed
WO-2010057920-A2 METHOD FOR MAKING UP OR CARING FOR EYELASHES OR EYEBROWS USING A POLYALKENE-BASED SUPRAMOLECULAR POLYMER L'OREAL (FR) 2010-05-27 WO disclosed
EP-2189151-A1 Process for the makeup of skin and/or lips by applying a composition comprising a supramolecular polymer L'OREAL (FR) 2010-05-26 EP disclosed
EP-2189148-A2 Dye composition for keratin fibres comprising a supramolecular polymer based on polyalcene, a pigment and a volatile solvent L'OREAL (FR) 2010-05-26 EP disclosed
EP-2083791-A2 COMPOSITION FOR COLOURING KERATINOUS MATERIAL USING A SUPRA-MOLECULAR COLOURING SYSTEM L'Oreal (FR) 2009-08-05 EP disclosed
WO-2008059125-A2 COMPOSITION FOR COLOURING KERATINOUS MATERIAL USING A SUPRA-MOLECULAR COLOURING SYSTEM L'OREAL (FR) 2008-05-22 WO disclosed
EP-1797868-A1 Cosmetic composition comprising a (thio)urethane/(thio)urea copolymer capable of forming at least 3 hydrogen bonds, and process for cosmetic treatment L'Oréal (FR) 2007-06-20 EP disclosed
EP-1797867-A1 Cosmetic or pharmaceutical composition comprising a copolymer containing at least one ionisable group, and cosmetic treatment L'Oréal (FR) 2007-06-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190274946-A1 AQUEOUS DISPERSION OF POLYALKENE SUPRAMOLECULAR POLYMER AND ITS USE IN COSMETICS KRT18, DSG1, CUTA SMN1; SMN2 3608/4885TLR8 2127/4885MAPT 647/4885
US-10973751-B2 Hair dyeing process comprising a pigment and an aqueous dispersion of supramolecular polymer TYR, NACA, POLR1C SMN1; SMN2 3445/4885TLR8 3795/4885MAPT 707/4885
US-20200108007-A1 HAIR DYEING PROCESS COMPRISING A PIGMENT AND AN AQUEOUS DISPERSION OF SUPRAMOLECULAR POLYMER TYR, NACA, POLR1C SMN1; SMN2 3445/4885TLR8 3795/4885MAPT 707/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.