Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylthiouracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPO known ✓ | P07202 | 1/20 | 0.62 |
| ▸ | TAS2R38 | P59533 | 2/20 | 0.62 |
| ▸ | MPO | P05164 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | LPO | P22079 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | CYB5R3 | P00387 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylthiouracil SCHEMBL5493716 | 0.79 | LPO (1.00) | TAS2R38MPOTPOTSHRLPO | |
| Propylthiouracil SCHEMBL41239 | 0.79 | LPO (1.00) | TAS2R38MPOTPOTSHRLPO | |
| Propylthiouracil SCHEMBL27995248 | 0.78 | LPO (0.96) | TAS2R38MPOTPOTSHRLPO | |
| Propylthiouracil SCHEMBL28149476 | 0.72 | TAS2R38 (0.62) | TAS2R38MPOTPOTSHRLPO | |
| Propylthiouracil SCHEMBL13723721 | 0.72 | LPO (0.83) | TAS2R38MPOTPOTSHRLPO | |
| Benzylthiouracil SCHEMBL815137 | 0.72 | SMN1; SMN2 (1.00) | TAS2R38MPOTPOTSHRLPO | |
| Propylthiouracil SCHEMBL2322792 | 0.72 | CYP2C19 (0.76) | TAS2R38MPOTPOTSHRLPO | |
| SCHEMBL8407853 | 0.70 | KMT2A (0.90) | TAS2R38MPOTPOTSHRLPO | |
| Phenylmethylsulfonylfluoride SCHEMBL3965163 | 0.69 | PRSS1 (1.00) | TSHRSMN1; SMN2KMT2AFAAHPRSS1 | |
| Phenylmethylsulfonylfluoride SCHEMBL24938 | 0.69 | PRSS1 (1.00) | TSHRSMN1; SMN2KMT2AFAAHPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107018989-A | The application of a kind of red fire ant contact insecticide and ethiprole in killing red ant | 河南科技学院 | 2017-08-08 | — | — | CN | disclosed |
| CN-106719786-A | A kind of application of red fire ant contact insecticide and ethiprole in killing red ant | 河南科技学院 | 2017-05-31 | — | — | CN | disclosed |