Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807146 | 0.78 | TLR8 (0.55) | TLR8ALDH1A1KDM4EGAAIKBKB | |
| SCHEMBL15845644 | 0.77 | TLR8 (0.56) | TLR8ALDH1A1KDM4EGAAIKBKB | |
| SCHEMBL10859840 | 0.76 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAHPGDMAPT | |
| SCHEMBL27860753 | 0.76 | KMT2A (0.50) | ALDH1A1KDM4EGAAHPGDMAPT | |
| SCHEMBL29188858 | 0.76 | TSHR (0.42) | ALDH1A1KDM4EGAAHPGDMAPT | |
| SCHEMBL1975113 | 0.72 | NCF1 (0.51) | ALDH1A1KDM4EGAAHPGDMAPT | |
| SCHEMBL11539058 | 0.70 | TDP1 (0.49) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL29454362 | 0.70 | TLR8 (0.57) | TLR8ALDH1A1KDM4EGAAIKBKB | |
| SCHEMBL359102 | 0.70 | TLR8 (0.57) | TLR8ALDH1A1KDM4EGAAIKBKB | |
| Acridine SCHEMBL27860754 | 0.70 | ALDH1A1 (0.71) | TLR8ALDH1A1KDM4EGAAIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106699755-B | A kind of aza-acridine class compound and preparation method thereof and purposes | 清华大学深圳研究生院 | 2018-09-21 | — | — | CN | disclosed |
| CN-106699755-A | Aza-acridine compound and preparation method and application thereof | 清华大学深圳研究生院 | 2017-05-24 | — | — | CN | disclosed |