Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ampelopsin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 2/20 | 0.87 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.87 |
| ▸ | APP | P05067 | 1/20 | 0.87 |
| ▸ | XDH | P47989 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.67 |
| ▸ | RECQL | P46063 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | SLCO1B3 | Q9NPD5 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ampelopsin SCHEMBL22750858 | 0.93 | SYNJ2 (1.00) | SOSTSYNJ2APPXDHCYP3A4 | |
| Ampelopsin SCHEMBL29462401 | 0.93 | SYNJ2 (1.00) | SOSTSYNJ2APPXDHCYP3A4 | |
| Ampelopsin SCHEMBL29138729 | 0.93 | SYNJ2 (1.00) | SOSTSYNJ2APPXDHCYP3A4 | |
| Ampelopsin SCHEMBL29362330 | 0.93 | SYNJ2 (1.00) | SOSTSYNJ2APPXDHCYP3A4 | |
| Ampelopsin SCHEMBL723736 | 0.93 | SYNJ2 (1.00) | SOSTSYNJ2APPXDHCYP3A4 | |
| Ampelopsin SCHEMBL134532 | 0.93 | SYNJ2 (1.00) | SOSTSYNJ2APPXDHCYP3A4 | |
| Ampelopsin SCHEMBL134531 | 0.93 | SYNJ2 (1.00) | SOSTSYNJ2APPXDHCYP3A4 | |
| Ampelopsin SCHEMBL544092 | 0.92 | SYNJ2 (0.97) | SOSTSYNJ2APPXDHCYP3A4 | |
| Ampelopsin SCHEMBL30105905 | 0.91 | SOST (0.81) | SOSTSYNJ2APPXDHCYP3A4 | |
| Ampelopsin SCHEMBL16912881 | 0.91 | SOST (0.81) | SOSTSYNJ2APPXDHCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106770781-A | It is a kind of while determining five kinds of methods of flavones in Chinese herbal medicine or health products | 浙江省中药研究所有限公司 | 2017-05-31 | — | — | CN | disclosed |