Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | LCAT | P04180 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13131250 | 0.93 | HRH3 (0.53) | HRH4HRH3KCNH2HDAC1LCAT | |
| Trifluoroacetic Acid SCHEMBL3917783 | 0.85 | HRH4 (0.61) | HRH4HRH3LCATCYP3A4CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL5038086 | 0.81 | HRH4 (0.58) | HRH4HRH3LCATCYP3A4CYP2C9 | |
| SCHEMBL30328948 | 0.81 | ALDH1A1 (0.48) | HRH4HRH3MEN1USP2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL30327833 | 0.80 | ALDH1A1 (0.47) | HRH4HRH3MEN1USP2ALDH1A1 | |
| SCHEMBL485185 | 0.78 | RIPK1 (0.44) | HRH4HRH3KCNH2LCATRIPK1 | |
| SCHEMBL2850464 | 0.75 | HRH3 (0.59) | HRH4HRH3LCATUSP2ALDH1A1 | |
| SCHEMBL13168274 | 0.74 | HRH3 (0.57) | HRH4HRH3KCNH2HDAC1MEN1 | |
| Trifluoroacetic Acid SCHEMBL26599646 | 0.73 | HRH4 (0.63) | HRH4HRH3CYP3A4CYP2C9HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL5038083 | 0.73 | HRH4 (0.52) | HRH4HRH3LCATCYP2C9HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | HRH4 47/4885HRH3 93/4885KCNH2 257/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | HRH4 47/4885HRH3 93/4885KCNH2 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.