Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ASPH | Q12797 | 1/20 | 0.31 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10562435 | 0.78 | LMNA (0.35) | ALDH1A1ALOX15KDM5BKDM4EHCAR2 | |
| SCHEMBL5769273 | 0.71 | KDM4E (0.52) | ALDH1A1ALOX15KDM5BKDM4EASPH | |
| SCHEMBL277947 | 0.70 | SMN1; SMN2 (0.35) | ALDH1A1KDM5BKDM4EASPHKDM8 | |
| SCHEMBL890368 | 0.70 | KDM4E (0.55) | ALDH1A1ALOX15KDM4E | |
| SCHEMBL28309038 | 0.70 | SIRT3 (0.38) | ALDH1A1KDM5BKDM4E | |
| Hydrochloric Acid SCHEMBL28182285 | 0.68 | KDM4E (0.53) | ALDH1A1ALOX15KDM4E | |
| SCHEMBL15303931 | 0.68 | KDM4E (0.46) | ALDH1A1ALOX15KDM4EASPHKDM8 | |
| SCHEMBL21408746 | 0.66 | P2RX7 (0.46) | ALDH1A1KDM5BKDM4E | |
| SCHEMBL4117073 | 0.65 | KDM4E (0.47) | ALDH1A1KDM5BKDM4E | |
| SCHEMBL5120006 | 0.65 | KDM4E (0.44) | ALDH1A1ALOX15KDM5BKDM4EASPH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104892582-B | Azetidine as the mek inhibitor for treating proliferative disease | 埃克塞利希斯股份有限公司 | 2019-09-27 | — | — | CN | disclosed |
| CN-109053523-A | Azetidine as the mek inhibitor for treating proliferative disease | 埃克塞利希斯股份有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-103524392-B | As for treating the azetidine of the MEK inhibitor of proliferative disease | 埃克塞利希斯股份有限公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-106986872-A | Bromine domain inhibitor | 艾伯维公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-104136435-B | bromodomain inhibitors | 艾伯维公司 | 2017-05-10 | — | — | CN | disclosed |