Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16146526 | 0.89 | ADORA3 (0.43) | ADORA3ADORA1ADORA2AMAPTPIK3CA | |
| SCHEMBL18670632 | 0.83 | LMNA (0.33) | GABRR1ALDH1A1LMNAPOLB | |
| SCHEMBL27157690 | 0.81 | LMNA (0.33) | ADORA3GABRR1ALDH1A1LMNA | |
| SCHEMBL19738337 | 0.81 | SYK (0.39) | MAPT | |
| SCHEMBL4430662 | 0.79 | XDH (0.39) | — | |
| SCHEMBL29654971 | 0.76 | BRD4 (0.40) | TSHRNPC1RAB9A | |
| SCHEMBL22118770 | 0.76 | BRD4 (0.40) | TSHRNPC1RAB9A | |
| SCHEMBL16146678 | 0.75 | GDA (0.39) | ADORA3ADORA2APIK3CAMTORGDA | |
| SCHEMBL6509982 | 0.75 | — | — | |
| SCHEMBL16146880 | 0.75 | CRHR1 (0.36) | ADORA3PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107337659-A | Compounds as protein kinase modulators | 理森制药股份公司 | 2017-11-10 | — | — | CN | disclosed |
| CN-103702989-B | Novel compounds as modulators of protein kinases | 理森制药股份公司 | 2017-07-07 | — | — | CN | disclosed |