Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18537911 | 1.00 | NPSR1 (0.43) | NPSR1RAB9AL3MBTL1HDAC3HDAC4 | |
| SCHEMBL10003003 | 0.91 | ALOX5 (0.43) | NPSR1L3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL10003002 | 0.91 | ALOX5 (0.43) | NPSR1L3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL20291498 | 0.89 | ALDH1A1 (0.48) | RAB9AL3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL10003527 | 0.89 | ALDH1A1 (0.48) | RAB9AL3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL10003531 | 0.89 | ALDH1A1 (0.48) | RAB9AL3MBTL1HDAC3HDAC4HDAC1 | |
| SCHEMBL29500522 | 0.88 | NOD2 (0.42) | NPSR1RAB9AL3MBTL1HDAC3HDAC4 | |
| SCHEMBL10002620 | 0.88 | NOD2 (0.42) | NPSR1RAB9AL3MBTL1HDAC3HDAC4 | |
| SCHEMBL10002618 | 0.88 | NOD2 (0.42) | NPSR1RAB9AL3MBTL1HDAC3HDAC4 | |
| SCHEMBL18537950 | 0.88 | HTR6 (0.39) | NPSR1RAB9AL3MBTL1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3339305-B1 | INDOLE DERIVATIVE, PREPARATION METHOD THEREOF, AND USE THEREOF IN PHARMACEUTICAL DRUG | ZHEJIANG HISUN PHARM CO LTD (CN) | 2022-05-04 | — | — | EP | disclosed |
| CN-107406431-B | Indole derivatives, preparation method and medical application thereof | 上海昂睿医药技术有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-107406431-A | Indole derivatives and preparation method thereof and its purposes in medicine | 浙江海正药业股份有限公司 | 2017-11-28 | — | — | CN | disclosed |