Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.53 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.53 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 5/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2817248 | 1.00 | TAS1R3 (0.53) | TAS1R3TAS1R1TAS1R2PDE10AHPGDS | |
| SCHEMBL15226670 | 0.92 | TAS1R3 (0.52) | TAS1R3TAS1R1TAS1R2PDE10AHPGDS | |
| SCHEMBL13131204 | 0.92 | TAS1R3 (0.52) | TAS1R3TAS1R1TAS1R2PDE10AHPGDS | |
| SCHEMBL2820001 | 0.89 | PDE10A (0.51) | TAS1R3TAS1R1TAS1R2PDE10AHPGDS | |
| SCHEMBL2819996 | 0.89 | PDE10A (0.51) | TAS1R3TAS1R1TAS1R2PDE10AHPGDS | |
| SCHEMBL484459 | 0.85 | HPGDS (0.59) | TAS1R3TAS1R1PDE10AHPGDSPDE4A | |
| SCHEMBL2816607 | 0.85 | HPGDS (0.59) | TAS1R3TAS1R1PDE10AHPGDSPDE4A | |
| SCHEMBL784559 | 0.84 | HPGD (0.55) | TAS1R3TAS1R1TAS1R2PDE10APDE4A | |
| SCHEMBL784560 | 0.84 | HPGD (0.55) | TAS1R3TAS1R1TAS1R2PDE10APDE4A | |
| SCHEMBL785249 | 0.82 | ALDH1A1 (0.61) | TAS1R3TAS1R1TAS1R2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | TAS1R3 339/4885TAS1R1 107/4885TAS1R2 282/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | TAS1R3 339/4885TAS1R1 107/4885TAS1R2 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.