⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28227350 | 0.78 | — | — | |
| SCHEMBL28175196 | 0.78 | — | — | |
| SCHEMBL15285775 | 0.77 | STK17B (0.34) | — | |
| SCHEMBL25857099 | 0.77 | HCAR1 (0.31) | — | |
| SCHEMBL24052556 | 0.75 | — | — | |
| SCHEMBL20127004 | 0.75 | — | — | |
| SCHEMBL28294705 | 0.75 | CCNB2 (0.31) | — | |
| SCHEMBL20959564 | 0.75 | CCNT1 (0.30) | — | |
| SCHEMBL30292479 | 0.73 | DCTPP1 (0.40) | — | |
| SCHEMBL1995080 | 0.73 | CCND1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108434149-A | For the regulated treatments of HSPC of Rb positive abnormal cell proliferations | G1治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105407889-B | HSPC-sparing therapy for Rb-positive abnormal cell proliferation | G1治疗公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-105473140-B | Transient protection of normal cells during chemotherapy | G1治疗公司 | 2018-04-10 | — | — | CN | disclosed |
| CN-107417691-A | Efficient anti-superfluous raw agent and anti-proliferative agent | G1治疗公司 | 2017-12-01 | — | — | CN | disclosed |