Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | PPM1D | O15297 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27875069 | 0.95 | ALDH1A1 (0.46) | BRS3ALDH1A1ALOX15KDM5BKMT2A | |
| SCHEMBL28165784 | 0.92 | ALDH1A1 (0.44) | BRS3ALDH1A1ALOX15CCR3KDM4C | |
| SCHEMBL27875223 | 0.82 | CCR3 (0.38) | ALDH1A1ALOX15KDM5BKDM5ACCR3 | |
| SCHEMBL2468476 | 0.81 | MMP2 (0.49) | BRS3ALDH1A1ALOX15CCR3KDM4E | |
| SCHEMBL28074770 | 0.78 | SLC6A1 (0.46) | ALDH1A1KMT2A | |
| SCHEMBL28175595 | 0.77 | BRS3 (0.46) | BRS3ALDH1A1KMT2AACLYKDM4C | |
| SCHEMBL14660228 | 0.76 | CHRNB4 (0.42) | ALDH1A1KMT2AKDM4E | |
| SCHEMBL28871862 | 0.76 | KDM4E (0.41) | ALDH1A1TSHRKDM4E | |
| SCHEMBL7298560 | 0.75 | PPM1D (0.53) | BRS3ALDH1A1ALOX15KDM5BKMT2A | |
| SCHEMBL10790692 | 0.75 | HMGB1 (0.51) | BRS3ALDH1A1KDM5BKMT2AKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074861-A | 9H pyrimido [4,5-B ] indoles and related analogs as BET bromodomain inhibitors | 密执安大学评议会 | 2017-08-18 | — | — | CN | disclosed |