Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377143 | 0.80 | POLB (0.63) | POLBTHRBSMN1; SMN2HPGDAPP | |
| SCHEMBL4538513 | 0.80 | HPGD (0.49) | SYKPOLBTHRBSMN1; SMN2HPGD | |
| SCHEMBL13443841 | 0.79 | HTR1A (0.57) | SYKAPPHTR1AADRA1DADRA1A | |
| SCHEMBL526387 | 0.75 | LOXL2 (0.48) | SYKPOLBTHRBSMN1; SMN2HPGD | |
| SCHEMBL13876457 | 0.75 | LOXL2 (0.48) | SYKPOLBTHRBSMN1; SMN2HPGD | |
| SCHEMBL17941862 | 0.73 | MET (0.50) | SMN1; SMN2IRAK4LMNAMETKDM4E | |
| SCHEMBL25312393 | 0.72 | SMN1; SMN2 (0.50) | POLBTHRBSMN1; SMN2HPGDADRA1A | |
| SCHEMBL23652014 | 0.72 | CYP3A4 (0.55) | APPMET | |
| SCHEMBL7834552 | 0.71 | CYP2A6 (0.44) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL309719 | 0.70 | KDM4E (0.46) | POLBSMN1; SMN2HPGDADRA1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107438598-A | QUINAZOLINE AND QUINOLINE COMPOUNDS AND USES THEREOF | 米伦纽姆医药公司 | 2017-12-05 | — | — | CN | disclosed |