Sulfurein

Sulfurein

SCHEMBL2817568

O=C1C(=Cc2ccc(O)c(O)c2)Oc2cc(O[C@@H]3OC(CO)[C@@H](O)[C@H](O)C3O)ccc21

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK5 Q00535 3/20 0.77
CDK5R1 Q15078 2/20 0.77
MEN1 O00255 4/20 0.71
KMT2A Q03164 4/20 0.71
STK17B O94768 4/20 0.53
RECQL P46063 3/20 0.53
AURKA O14965 3/20 0.53
GSK3B P49841 3/20 0.53
GAA P10253 3/20 0.53
DAPK3 O43293 2/20 0.53
BLK P51451 2/20 0.53
TEK Q02763 2/20 0.53
BTK Q06187 2/20 0.53
ITK Q08881 2/20 0.53
STK17A Q9UEE5 2/20 0.53
DAPK2 Q9UIK4 2/20 0.53
KDM4E B2RXH2 2/20 0.53
MAPT P10636 2/20 0.53
PSMD14 O00487 1/20 0.53
NPC1 O15118 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sulfurein SCHEMBL29462894 1.00 CDK5 (0.77) CDK5CDK5R1MEN1KMT2ASTK17B
SCHEMBL29362331 0.87 CDK5 (1.00) CDK5CDK5R1MEN1KMT2ARECQL
Maritimein SCHEMBL1706306 0.83 MEN1 (1.00) CDK5CDK5R1MEN1KMT2AGAA
Maritimein SCHEMBL29354648 0.83 MEN1 (1.00) CDK5CDK5R1MEN1KMT2AGAA
Maritimein SCHEMBL1706313 0.83 MEN1 (1.00) CDK5CDK5R1MEN1KMT2AGAA
SCHEMBL1043781 0.81 CDK5 (0.80) CDK5CDK5R1MEN1KMT2ASTK17B
SCHEMBL13324395 0.81 MEN1 (0.66) CDK5CDK5R1MEN1KMT2ASTK17B
SCHEMBL31360843 0.80 MEN1 (0.81) CDK5CDK5R1MEN1KMT2AGAA
SCHEMBL1098173 0.80 MEN1 (0.81) CDK5CDK5R1MEN1KMT2AGAA
Z-Astringin SCHEMBL501245 0.74 POLB (0.81) CDK5CDK5R1MEN1KMT2ARECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100247464-A1 COSMETIC COMPOSITION HAVING ANTI-RADICAL PROPERTIES AND CORRESPONDING APPLICATION METHOD YVES SAINT LAURENT PARFUMS (FR) 2010-09-30 US claimed
US-8475848-B2 Cosmetic composition having anti-radical properties and corresponding application method YVES SAINT LAURENT PARFUMS (FR) 2013-07-02 US disclosed
US-20100247464-A1 COSMETIC COMPOSITION HAVING ANTI-RADICAL PROPERTIES AND CORRESPONDING APPLICATION METHOD YVES SAINT LAURENT PARFUMS (FR) 2010-09-30 US disclosed
US-20090221690-A1 Pharmaceutical Composition for the Prevention/Treatment of Bone Disorders and a Process for the Preparation Thereof COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (US) 2009-09-03 US disclosed
EP-1993579-A2 A PHARMACEUTICAL COMPOSITION FOR THE PREVENTION/TREATMENT OF BONE DISORDERS AND A PROCESS FOR THE PREPARATION THEREOF Council of Scientific and Industrial Research (IN) 2008-11-26 EP disclosed
WO-2007099432-A2 PHARMACEUTICAL COMPOSITION CONTAINING BUTEA ISOFLAVONES FOR THE PREVENTION /TREATMENT OF BONE DISORDERS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2007-09-07 WO disclosed
US-20060228313-A1 Method of cosmetic depigmentation care by applying at least one aurone COLETICA (FR) 2006-10-12 US disclosed
EP-1709964-A2 A method of cosmetic depigmentation care by applying at least one aurone ENGELHARD LYON (FR) 2006-10-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060228313-A1 Method of cosmetic depigmentation care by applying at least one aurone TYR, MITF, MC1R CDK5 2550/4885CDK5R1 3200/4885MEN1 2351/4885
US-20100247464-A1 COSMETIC COMPOSITION HAVING ANTI-RADICAL PROPERTIES AND CORRESPONDING APPLICATION METHOD CUTA, CAT, PRDX3 CDK5 4009/4885CDK5R1 3921/4885MEN1 4622/4885
US-20090221690-A1 Pharmaceutical Composition for the Prevention/Treatment of Bone Disorders and a Process for the Preparation Thereof SOST, BPGM, PTMS CDK5 673/4885CDK5R1 1290/4885MEN1 197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.