Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | PRKCA | P17252 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CCND1 | P24385 | 2/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2310834 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTMAPTMEN1 | |
| SCHEMBL28166035 | 0.77 | CDK4 (0.43) | PABPC1MAPTMEN1KMT2AAHR | |
| SCHEMBL28054157 | 0.74 | PIM1 (0.46) | ALDH1A1TSHRHTTCHEK1DYRK1A | |
| SCHEMBL27648564 | 0.73 | JAK2 (0.53) | ALDH1A1HTTPABPC1MAPT | |
| SCHEMBL2311119 | 0.70 | IMPDH2 (0.55) | ALDH1A1TSHRHTTMAPTMEN1 | |
| SCHEMBL5219876 | 0.69 | TSHR (0.41) | ALDH1A1TSHRPABPC1HPGD | |
| SCHEMBL27973848 | 0.68 | IMPDH2 (0.49) | ALDH1A1HTTPABPC1MAPTMEN1 | |
| SCHEMBL28188584 | 0.68 | POLB (0.55) | ALDH1A1HTTPABPC1MAPTMEN1 | |
| SCHEMBL28183977 | 0.67 | KIF11 (0.51) | ALDH1A1TSHRHTTMAPTMEN1 | |
| SCHEMBL573589 | 0.67 | KIF11 (0.50) | ALDH1A1TSHRHTTMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105358546-B | The tetrahydro carbazole being substituted and carbazole carboxamide compounds useful as kinase inhibitor | 百时美施贵宝公司 | 2017-10-31 | — | — | CN | disclosed |