SCHEMBL28181536

SCHEMBL28181536

O=[N+]([O-])c1ccccc1CCc1ccccc1O

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.58
TSHR P16473 1/20 0.58
GPR35 Q9HC97 2/20 0.53
HPGD P15428 1/20 0.53
TAAR1 Q96RJ0 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
CTSB P07858 1/20 0.47
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C19 P33261 1/20 0.45
KCNMA1 Q12791 1/20 0.45
HTT P42858 1/20 0.45
HSPA5 P11021 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3202573 0.88 ALDH1A1 (0.72) ALDH1A1TSHRGPR35HPGDL3MBTL1
SCHEMBL1246296 0.87 HSPA5 (0.59) ALDH1A1TSHRGPR35HPGDL3MBTL1
SCHEMBL27973507 0.83 TSHR (0.45) ALDH1A1TSHRGPR35SMN1; SMN2MEN1
SCHEMBL27279753 0.83 ALDH1A1 (0.52) ALDH1A1TSHRGPR35HPGDL3MBTL1
SCHEMBL20817180 0.80 ALDH1A1 (0.53) ALDH1A1TSHRGPR35HPGDL3MBTL1
SCHEMBL249846 0.80 ALDH1A1 (0.68) ALDH1A1TSHRGPR35HPGDL3MBTL1
Nitrophenolate SCHEMBL29360402 0.79 GPR35 (0.65) ALDH1A1TSHRGPR35HPGDL3MBTL1
Catechol SCHEMBL28052795 0.79 GPR35 (0.65) ALDH1A1GPR35HPGDL3MBTL1CTSB
Nitrophenolate SCHEMBL26026 0.79 GPR35 (0.65) ALDH1A1TSHRGPR35HPGDL3MBTL1
Nitrophenolate SCHEMBL28029048 0.79 GPR35 (0.65) ALDH1A1TSHRGPR35HPGDL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107188771-A Chiral synthesis method of gamma-nitrophenol compound 浙江工业大学 2017-09-22 CN disclosed