Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 9/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RARA | P10276 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL11519115 | 0.92 | TP53 (0.57) | RARBTP53TSHRALDH1A1PLA2G4B | |
| Terephthalic Acid SCHEMBL27832793 | 0.92 | TP53 (0.57) | RARBTP53TSHRALDH1A1PLA2G4B | |
| Terephthalic Acid SCHEMBL9805332 | 0.92 | TP53 (0.57) | RARBTP53TSHRALDH1A1PLA2G4B | |
| Terephthalic Acid SCHEMBL15015693 | 0.92 | TP53 (0.57) | RARBTP53TSHRALDH1A1PLA2G4B | |
| Terephthalic Acid SCHEMBL29199831 | 0.84 | RARB (0.53) | RARBTP53TSHRALDH1A1PLA2G4B | |
| Terephthalic Acid SCHEMBL3842017 | 0.84 | TP53 (0.53) | RARBTP53TSHRALDH1A1PLA2G4B | |
| Terephthalic Acid SCHEMBL1884274 | 0.83 | RARB (0.68) | RARBTP53TSHRALDH1A1PLA2G4B | |
| Terephthalic Acid SCHEMBL27433040 | 0.83 | RARB (0.64) | RARBTP53TSHRALDH1A1PLA2G4B | |
| Terephthalic Acid SCHEMBL2944670 | 0.83 | RARB (0.68) | RARBTP53TSHRALDH1A1PLA2G4B | |
| SCHEMBL39429 | 0.82 | CA2 (0.61) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531989-A | resin composition and electrical insulating sheet | 日东新兴有限公司 | 2018-01-02 | — | — | CN | disclosed |