Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10953892 | 0.81 | MAPT (0.41) | KDM4EALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL528504 | 0.80 | GABRA1 (0.39) | MAPK1NPSR1KDM4EALDH1A1LMNA | |
| SCHEMBL10963157 | 0.78 | SMN1; SMN2 (0.39) | MAPK1NPSR1KDM4EALDH1A1LMNA | |
| SCHEMBL28170245 | 0.73 | SMARCA2 (0.44) | NPSR1KDM4EALDH1A1LMNAGLA | |
| SCHEMBL11516978 | 0.73 | DHFR (0.42) | KDM4EALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL28145719 | 0.71 | ADORA2A (0.41) | MAPK1NPSR1KDM4EALDH1A1LMNA | |
| SCHEMBL115757 | 0.70 | MAPK1 (0.52) | MAPK1NPSR1KDM4ELMNASMARCA2 | |
| SCHEMBL723656 | 0.70 | GRIA1 (0.43) | MAPK1KDM4EALDH1A1LMNAGLA | |
| SCHEMBL28152930 | 0.68 | LMNA (0.41) | MAPK1NPSR1KDM4EALDH1A1LMNA | |
| SCHEMBL30239892 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531668-A | Therapeutic pyridazine compound and application thereof | 基因泰克公司 | 2018-01-02 | — | — | CN | disclosed |