SCHEMBL723656

SCHEMBL723656

Clc1cncc(Cl)c1-c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 1/20 0.43
CACNG8 Q8WXS5 1/20 0.43
ATM Q13315 2/20 0.42
CYP2A6 P11509 1/20 0.42
ALDH1A1 P00352 4/20 0.41
MAPT P10636 3/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
KDM4E B2RXH2 2/20 0.41
GLA P06280 2/20 0.41
MAPK1 P28482 2/20 0.41
GAA P10253 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
LMNA P02545 3/20 0.40
CYP1A2 P05177 1/20 0.40
HTT P42858 1/20 0.40
NOTUM Q6P988 1/20 0.40
HPGD P15428 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL308199 0.76 CYP2A6 (0.55) GRIA1CACNG8CYP2A6ALDH1A1MAPT
SCHEMBL21881930 0.75 AKT2 (0.43) ATMALDH1A1MAPTKMT2ALMNA
SCHEMBL14886625 0.74 RXRA (0.53) GRIA1CACNG8TSHR
SCHEMBL2932603 0.74 AHR (0.52) CYP2A6ALDH1A1MAPTMEN1KMT2A
SCHEMBL528504 0.73 GABRA1 (0.39) ATMCYP2A6ALDH1A1MAPTMEN1
SCHEMBL15543810 0.73 ALDH1A1 (0.41) ATMCYP2A6ALDH1A1MAPTMEN1
SCHEMBL16939188 0.72 ESR2 (0.52) CYP2A6ALDH1A1MAPTMEN1KMT2A
Hydrogen Sulfide SCHEMBL11666785 0.72 AHR (0.50) CYP2A6ALDH1A1MAPTMEN1KMT2A
SCHEMBL5331238 0.72 ATM (0.63) ATMCYP2A6ALDH1A1MAPTMEN1
SCHEMBL1524405 0.72 CYP2A6 (0.45) ATMCYP2A6ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 252 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026090602-A1 PIGMENTED RESIN AND CATALYST COMPOSITIONS MATERIA, INC. (US) 2026-04-30 WO disclosed
EP-3110862-B1 ADHESION PROMOTER COMPOSITIONS FOR CYCLIC OLEFIN RESIN COMPOSITIONS ExxonMobil Product Solutions Company (US) 2026-04-01 EP disclosed
EP-4683900-A2 ROMP AND THERMAL INSULATION COMPOSITIONS AND MATERIALS AND USE THEREOF Materia, Inc. (US) 2026-01-28 EP disclosed
WO-2025245037-A1 CYCLIC OLEFIN COMPOSITIONS, ROMP COMPOSITIONS THEREOF, AND APPLICATIONS THEREOF MATERIA, INC. (US) 2025-11-27 WO disclosed
EP-4194092-B1 SYNTHESIS AND CHARACTERIZATION OF METATHESIS CATALYSTS UMICORE AG & CO KG (DE) 2025-10-22 EP disclosed
EP-2970522-B1 IN-MOLD COATING OF ROMP POLYMERS MATERIA INC (US) 2025-05-21 EP disclosed
EP-3013886-B1 THERMAL INSULATION MATERIA INC (US) 2025-03-26 EP disclosed
EP-2961778-B1 METAL CARBENE OLEFIN METATHESIS TWO CATALYST COMPOSITION MATERIA INC (US) 2025-02-26 EP disclosed
US-20250026871-A1 CYCLIC RUTHENIUM BENZYLIDENE INITIATORS FOR ENHANCED RING EXPANSION METATHESIS POLYMERIZATION UNIVERSITY OF WASHINGTON (US) 2025-01-23 US disclosed
EP-4455207-A2 LIQUID MOLDING COMPOSITIONS Materia, Inc. (US) 2024-10-30 EP disclosed
WO-2008008440-A2 RING OPENING CROSS-METATHESIS REACTION OF CYCLIC OLEFINS WITH SEED OILS AND THE LIKE ELEVANCE RENEWABLE SCIENCES, INC. (US) 2008-01-17 WO disclosed
EP-1497299-A4 CROSS-METATHESIS OF OLEFINS DIRECTLY SUBSTITUTED WITH AN ELECTRON-WITHDRAWING GROUP USING TRANSITION METAL CARBENE CATALYSTS CALIFORNIA INST OF TECHN (US) 2006-08-02 EP disclosed
EP-1543043-A4 SYNTHESIS OF MACROCYCLIC POLYMERS BY RING INSERTION POLYMERIZATION OF CYCLIC OLEFIN MONOMERS CALIFORNIA INST OF TECHN (US) 2005-11-02 EP disclosed
US-6946533-B2 Synthesis of macrocyclic polymers by ring insertion polymerization of cyclic olefin monomers CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2005-09-20 US disclosed
EP-1543043-A2 SYNTHESIS OF MACROCYCLIC POLYMERS BY RING INSERTION POLYMERIZATION OF CYCLIC OLEFIN MONOMERS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2005-06-22 EP disclosed
EP-1497299-A2 CROSS-METATHESIS OF OLEFINS DIRECTLY SUBSTITUTED WITH AN ELECTRON-WITHDRAWING GROUP USING TRANSITION METAL CARBENE CATALYSTS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2005-01-19 EP disclosed
US-20040132934-A1 Synthesis of macrocyclic polymers by ring insertion polymerization of cyclic olefin monomers CALIFORNIA INSTITUTE OF TECHNOLOGY 2004-07-08 US disclosed
WO-2004013198-A2 SYNTHESIS OF MACROCYCLIC POLYMERS BY RING INSERTION POLYMERIZATION OF CYCLIC OLEFIN MONOMERS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2004-02-12 WO disclosed
US-20030236427-A1 Cross-metathesis of olefins directly substituted with an electron-withdrawing group using transition metal carbene catalysts NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-12-25 US disclosed
WO-2003087167-A2 CROSS-METATHESIS OF OLEFINS DIRECTLY SUBSTITUTED WITH AN ELECTRON-WITHDRAWING GROUP USING TRANSITION METAL CARBENE CATALYSTS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2003-10-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030236427-A1 Cross-metathesis of olefins directly substituted with an electron-withdrawing group using transition metal carbene catalysts OXER1, DUOX2, AOC2 GRIA1 998/4885CACNG8 1074/4885ATM 1627/4885
US-20250026871-A1 CYCLIC RUTHENIUM BENZYLIDENE INITIATORS FOR ENHANCED RING EXPANSION METATHESIS POLYMERIZATION MCM7, MCM4, MCM5 GRIA1 2907/4885CACNG8 1963/4885ATM 2945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.