Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 8/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrazine SCHEMBL28200066 | 0.82 | TP53 (0.88) | TP53TSHRMAPK1HSD17B10ALDH1A1 | |
| Hydrazine SCHEMBL28200142 | 0.79 | TP53 (0.82) | TP53TSHRMAPK1HSD17B10ALDH1A1 | |
| Sulfuric Acid SCHEMBL28200091 | 0.78 | TP53 (0.64) | TP53TSHRHSD17B10ALDH1A1FLT1 | |
| Phosphoric Acid SCHEMBL28200084 | 0.78 | TP53 (0.64) | TP53TSHRHSD17B10ALDH1A1FLT1 | |
| Oxalic Acid SCHEMBL28856224 | 0.78 | TP53 (0.64) | TP53TSHRMAPK1HSD17B10ALDH1A1 | |
| 1,2-Dichlorobenzene SCHEMBL28200720 | 0.78 | LMNA (0.50) | TSHRMAPK1HSD17B10ALDH1A1CYP3A4 | |
| Nitric Acid SCHEMBL20984758 | 0.77 | MAPT (0.50) | TSHRMAPK1ALDH1A1KDM4EMAPT | |
| Nitric Acid SCHEMBL20984328 | 0.77 | CA1 (0.50) | TP53TSHRMAPK1ALDH1A1KDR | |
| 1,3,5-Trichlorobenzene SCHEMBL28200723 | 0.77 | ALDH1A1 (0.48) | TP53TSHRMAPK1ALDH1A1CYP3A4 | |
| 1,4-Dichlorobenzene SCHEMBL29002852 | 0.77 | FBP1 (0.52) | TSHRMAPK1ALDH1A1CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107663161-A | A kind of continuous stream synthesis technique of phenylhydrazine salt and substituted benzene hydrazonium salt | 上海惠和化德生物科技有限公司 | 2018-02-06 | — | — | CN | disclosed |