Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19142282 | 0.76 | CYP11B1 (0.36) | NPC1RAB9ACYP19A1CYP11B1CYP11B2 | |
| SCHEMBL28201589 | 0.75 | CHRM2 (0.30) | CHRM2HTR1ACHRM1DRD2HTR2A | |
| SCHEMBL28857380 | 0.73 | HRH1 (0.34) | CHRM2HTR1ACHRM1DRD2HTR2A | |
| SCHEMBL4340785 | 0.73 | TSHR (0.32) | CHRM2HTR1ACHRM1DRD2HTR2A | |
| SCHEMBL28202178 | 0.72 | HDAC8 (0.32) | CHRM2HTR1ACHRM1DRD2HTR2A | |
| SCHEMBL28195678 | 0.72 | HDAC1 (0.32) | NPC1RAB9ACHRM2HTR1ACHRM1 | |
| SCHEMBL7631306 | 0.72 | NOS3 (0.52) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28276888 | 0.72 | CYP11B2 (0.33) | CYP11B2CHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL28201579 | 0.68 | HRH1 (0.35) | ALDH1A1CHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL28201586 | 0.68 | CYP2A6 (0.36) | NPC1RAB9AALDH1A1CHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683188-B | The ring pyridinyl derivatives of condensed ring two as FGFR4 inhibitor | 诺华股份有限公司 | 2018-02-09 | — | — | CN | disclosed |