Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28857380 | 0.78 | HRH1 (0.34) | HTR2AHTR2CHTR2BCHRM2HTR1A | |
| SCHEMBL4340785 | 0.78 | TSHR (0.32) | HTR2AHTR2CHTR2BCHRM2HTR1A | |
| SCHEMBL28195678 | 0.76 | HDAC1 (0.32) | HTR2AHTR2CHTR2BCHRM2HTR1A | |
| SCHEMBL28276888 | 0.76 | CYP11B2 (0.33) | HTR2AHTR2CHTR2BCHRM2HTR1A | |
| SCHEMBL19142282 | 0.76 | CYP11B1 (0.36) | HTR2AHTR2CHTR2BCHRM2HTR1A | |
| SCHEMBL28201589 | 0.72 | CHRM2 (0.30) | HTR2AHTR2CHTR2BCHRM2HTR1A | |
| SCHEMBL28202171 | 0.72 | EP300 (0.31) | — | |
| SCHEMBL28201612 | 0.72 | NPC1 (0.33) | HTR2AHTR2CHTR2BCHRM2HTR1A | |
| SCHEMBL28201595 | 0.72 | L3MBTL1 (0.36) | — | |
| SCHEMBL29077469 | 0.69 | NOS3 (0.37) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683188-B | The ring pyridinyl derivatives of condensed ring two as FGFR4 inhibitor | 诺华股份有限公司 | 2018-02-09 | — | — | CN | disclosed |