Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28201586 | 0.78 | CYP2A6 (0.36) | ALDH1A1HDAC1HDAC6NPC1LMNA | |
| SCHEMBL28201579 | 0.78 | HRH1 (0.35) | ALDH1A1KDM4ELMNAADRA2AADRA2B | |
| SCHEMBL28857380 | 0.73 | HRH1 (0.34) | HDAC1HDAC6LMNASMN1; SMN2ADRA2A | |
| SCHEMBL4340785 | 0.73 | TSHR (0.32) | HDAC1HDAC6LMNA | |
| SCHEMBL28195678 | 0.72 | HDAC1 (0.32) | HDAC1HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28202178 | 0.72 | HDAC8 (0.32) | — | |
| SCHEMBL28276888 | 0.72 | CYP11B2 (0.33) | KDM4E | |
| SCHEMBL19142282 | 0.72 | CYP11B1 (0.36) | L3MBTL1MKNK1MKNK2NPC1RAB9A | |
| SCHEMBL29077469 | 0.69 | NOS3 (0.37) | ALDH1A1HDAC1HDAC6MKNK1MKNK2 | |
| SCHEMBL28201612 | 0.68 | NPC1 (0.33) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683188-B | The ring pyridinyl derivatives of condensed ring two as FGFR4 inhibitor | 诺华股份有限公司 | 2018-02-09 | — | — | CN | claimed |
| CN-109922804-A | COMBINATIONS OF FGFR4 INHIBITORS AND BILE ACID SEQUESTRANTS | 诺华股份有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-105683188-B | The ring pyridinyl derivatives of condensed ring two as FGFR4 inhibitor | 诺华股份有限公司 | 2018-02-09 | — | — | CN | disclosed |