Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | PRKACG | P22612 | 1/20 | 0.30 |
| ▸ | PRKACB | P22694 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28203028 | 0.78 | CDK4 (0.48) | MAOADYRK1ACDK4CCND1CDK1 | |
| SCHEMBL28851455 | 0.76 | BTK (0.39) | MAOADYRK1ACDK4CCND1CDK2 | |
| SCHEMBL149527 | 0.75 | BTK (0.47) | MAOADYRK1APARP1CDK4CCND1 | |
| SCHEMBL3690163 | 0.69 | KIF11 (0.41) | MAOADYRK1APARP1CDK4CCND1 | |
| SCHEMBL28177392 | 0.65 | ALDH1A1 (0.38) | DYRK1ACDK4CCND1CDK1CDK2 | |
| SCHEMBL28166025 | 0.64 | CDK4 (0.47) | CDK4CCND1CDK2 | |
| SCHEMBL20684923 | 0.64 | KDM5A (0.37) | — | |
| SCHEMBL149450 | 0.63 | BTK (0.49) | DYRK1ACDK2 | |
| SCHEMBL148529 | 0.62 | BTK (0.42) | CDK2 | |
| SCHEMBL16334012 | 0.62 | BTK (0.47) | MAOADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473573-B | Carbazole carboxamide compounds useful as kinase inhibitor | 百时美施贵宝公司 | 2018-03-16 | — | — | CN | disclosed |