Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.47 |
| ▸ | CCND1 | P24385 | 3/20 | 0.47 |
| ▸ | KIF11 | P52732 | 10/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28166035 | 0.79 | CDK4 (0.43) | CDK4CCND1MAPTCCNE2CCNE1 | |
| SCHEMBL28851455 | 0.77 | BTK (0.39) | CDK4CCND1CCNE2CCNE1CDK2 | |
| SCHEMBL28166026 | 0.73 | BTK (0.52) | CDK4CCND1KIF11BTKMPL | |
| SCHEMBL1758557 | 0.73 | MEN1 (0.48) | MAPTCA12CA9 | |
| SCHEMBL5438347 | 0.68 | KIF11 (0.60) | KIF11 | |
| SCHEMBL21563887 | 0.68 | CDK4 (0.56) | CDK4CCND1KIF11MAPTCA12 | |
| SCHEMBL28848039 | 0.67 | PKM (0.35) | MAPTBTK | |
| SCHEMBL10238280 | 0.66 | ALDH1A1 (0.50) | KIF11MAPTCA12CA9 | |
| SCHEMBL29643387 | 0.66 | RXFP1 (0.43) | KIF11MAPT | |
| SCHEMBL21885675 | 0.66 | RXFP1 (0.43) | KIF11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108555-A | Three ring atropisomer compounds | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-107074804-A | Carbazole derivates | 百时美施贵宝公司 | 2017-08-18 | — | — | CN | disclosed |