Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 2/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 6/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820261 | 1.00 | WDR5 (0.45) | WDR5TAS1R3TAS1R1TAS1R2CA12 | |
| SCHEMBL2818874 | 0.89 | RBP4 (0.45) | WDR5TAS1R3TAS1R1TAS1R2CA12 | |
| SCHEMBL2818878 | 0.89 | RBP4 (0.45) | WDR5TAS1R3TAS1R1TAS1R2CA12 | |
| SCHEMBL2818921 | 0.89 | TAS1R3 (0.51) | WDR5TAS1R3TAS1R1TAS1R2PDE4A | |
| SCHEMBL2818919 | 0.89 | TAS1R3 (0.51) | WDR5TAS1R3TAS1R1TAS1R2PDE4A | |
| SCHEMBL785761 | 0.85 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2CA12CA1 | |
| SCHEMBL785760 | 0.85 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2CA12CA1 | |
| SCHEMBL785669 | 0.84 | WDR5 (0.47) | WDR5TAS1R3TAS1R1TAS1R2PDE4A | |
| SCHEMBL785745 | 0.84 | WDR5 (0.47) | WDR5TAS1R3TAS1R1TAS1R2PDE4A | |
| SCHEMBL785748 | 0.82 | TAS1R3 (0.47) | WDR5TAS1R3TAS1R1TAS1R2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | WDR5 1762/4885TAS1R3 339/4885TAS1R1 107/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | WDR5 1762/4885TAS1R3 339/4885TAS1R1 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.