SCHEMBL28207152

SCHEMBL28207152

Cc1cc(C)cc(-c2nc(-c3ccccc3)c(-c3ccccc3)n2C)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 1/20 0.47
ADORA2A P29274 1/20 0.46
ADORA1 P30542 1/20 0.46
FABP4 P15090 2/20 0.46
FABP5 Q01469 1/20 0.46
KDM4E B2RXH2 3/20 0.46
ALDH1A1 P00352 3/20 0.46
HPGD P15428 2/20 0.46
TSHR P16473 1/20 0.46
HSD17B10 Q99714 1/20 0.46
TDP1 Q9NUW8 1/20 0.43
CNR1 P21554 3/20 0.43
L3MBTL1 Q9Y468 1/20 0.41
PDE10A Q9Y233 1/20 0.41
MAPK13 O15264 2/20 0.41
GCGR P47871 2/20 0.41
MAPK12 P53778 2/20 0.41
MAPK11 Q15759 2/20 0.41
MAPK14 Q16539 2/20 0.41
GAA P10253 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL822678 0.88 PTGER1 (0.56) PTGER1ADORA2AFABP4FABP5KDM4E
SCHEMBL28207145 0.80 FABP4 (0.50) ADORA2AADORA1FABP4FABP5KDM4E
SCHEMBL22219426 0.79 KMT2A (0.54) PTGER1FABP4FABP5KDM4EALDH1A1
SCHEMBL27934006 0.79 PTGER1 (0.49) PTGER1FABP4FABP5KDM4EALDH1A1
SCHEMBL15987599 0.79 PTGER1 (0.49) PTGER1ADORA2AFABP4FABP5KDM4E
SCHEMBL28857760 0.77 TP53 (0.56) ADORA2AADORA1KDM4EALDH1A1HPGD
SCHEMBL11516631 0.77 KDM4E (0.51) PTGER1KDM4EALDH1A1HPGDTSHR
SCHEMBL18152791 0.77 FABP4 (0.46) PTGER1FABP4FABP5KDM4EALDH1A1
SCHEMBL27881874 0.76 LMNA (0.59) PTGER1ADORA2AKDM4EALDH1A1TSHR
SCHEMBL19825896 0.75 FABP4 (0.54) PTGER1FABP4FABP5KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108026213-A Imidazoles and glyoxaline cation with special alkaline stability 康奈尔大学 2018-05-11 CN disclosed