Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 0.64 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.64 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL28455572 | 0.80 | TRPM8 (0.84) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL1664554 | 0.80 | TRPM8 (0.84) | TRPM8TRPA1EPHX1TRPV1 | |
| Racementhol SCHEMBL521946 | 0.80 | TRPM8 (1.00) | TRPM8TRPA1EPHX1TRPV1 | |
| (+) Neomenthol SCHEMBL260049 | 0.80 | TRPM8 (1.00) | TRPM8TRPA1EPHX1TRPV1 | |
| (+)-Menthol SCHEMBL1709231 | 0.80 | TRPM8 (1.00) | TRPM8TRPA1EPHX1TRPV1 | |
| (+)-Menthol SCHEMBL12646785 | 0.80 | TRPM8 (1.00) | TRPM8TRPA1EPHX1TRPV1 | |
| (+)-Menthol SCHEMBL13059620 | 0.80 | TRPM8 (1.00) | TRPM8TRPA1EPHX1TRPV1 | |
| (+)-Menthol SCHEMBL15449169 | 0.80 | TRPM8 (1.00) | TRPM8TRPA1EPHX1TRPV1 | |
| Menthol SCHEMBL20771511 | 0.80 | TRPM8 (1.00) | TRPM8TRPA1EPHX1TRPV1 | |
| (+)-Menthol SCHEMBL10072505 | 0.80 | TRPM8 (1.00) | TRPM8TRPA1EPHX1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109195450-A | Anti-coloring preparation | WM.雷格利 JR.公司 | 2019-01-11 | — | — | CN | disclosed |
| CN-108430228-A | Color indicates preparation | WM.雷格利 JR.公司 | 2018-08-21 | — | — | CN | disclosed |
| CN-107920571-A | Long-acting refrigerant preparation | WM.雷格利 JR.公司 | 2018-04-17 | — | — | CN | disclosed |