Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (+) Neomenthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 1.00 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+)-Menthol SCHEMBL10072505 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL15449169 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Isomenthol SCHEMBL677675 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Racementhol SCHEMBL521946 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL9968934 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL1709231 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL12646785 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL13059620 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL20771511 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL2454317 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 522 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12635710-B2 | Methods of using formaldehyde-free antimicrobial compositions in animal by-product compositions | EASTMAN CHEMICAL COMPANY (US) | 2026-05-26 | — | — | US | claimed |
| EP-4651713-A1 | PLANT TREATMENT COMPOSITIONS COMPRISING CHITOSAN-COATED EMULSIONS | Universität Münster (DE) | 2025-11-26 | — | — | EP | claimed |
| US-20250325463-A1 | COMPOSITIONS (III) | SYMRISE AG (DE) | 2025-10-23 | — | — | US | claimed |
| CN-119302445-A | Nicotine solid atomization preparation with efficacy of clearing throat and relieving sore throat | 深圳麦克韦尔科技有限公司 | 2025-01-14 | — | — | CN | claimed |
| EP-4472606-A1 | COMPOSITIONS (III) | Symrise AG (DE) | 2024-12-11 | — | — | EP | claimed |
| US-20240358611-A1 | COMPOSITIONS | SYMRISE AG (DE) | 2024-10-31 | — | — | US | claimed |
| CN-118787123-A | Water-based electronic cigarette atomization preparation and preparation method and application thereof | 思摩尔国际控股有限公司 | 2024-10-18 | — | — | CN | claimed |
| WO-2024212780-A1 | WATER-BASED ELECTRONIC CIGARETTE ATOMIZATION FORMULATION, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 思摩尔国际控股有限公司 | 2024-10-17 | — | — | WO | claimed |
| EP-4142508-B1 | MINT FLAVOR COMPOSITIONS | PROCTER & GAMBLE (US) | 2024-10-09 | — | — | EP | claimed |
| EP-4429465-A1 | COMPOSITIONS COMPRISING TRPM8 AGONISTIC COOLING AGENTS | Symrise AG (DE) | 2024-09-18 | — | — | EP | claimed |
| US-8445037-B2 | Volatile distillate by-product of mint oil that promotes absorption and/or bioavailability of compounds of bio-medical and nutritional interest | A. M. TODD COMPANY (US) | 2013-05-21 | — | — | US | claimed |
| EP-2459526-A1 | ORGANIC-SULPHIDE COMPOSITION WITH MASKED ODOUR | Arkema France (FR) | 2012-06-06 | — | — | EP | claimed |
| EP-2459527-A1 | SOLVENT COMPOSITION BASED ON AN OXIDE OF AN ORGANIC SULFIDE WITH MASKED ODOUR | Arkema France (FR) | 2012-06-06 | — | — | EP | claimed |
| WO-2011012820-A1 | SOLVENT COMPOSITION BASED ON AN OXIDE OF AN ORGANIC SULFIDE WITH MASKED ODOUR | ARKEMA FRANCE (FR) | 2011-02-03 | — | — | WO | claimed |
| WO-2011012815-A1 | ORGANIC-SULPHIDE COMPOSITION WITH MASKED ODOUR | ARKEMA FRANCE (FR) | 2011-02-03 | — | — | WO | claimed |
| US-20100197801-A1 | Volatile Distillate By-Product of Mint Oil That Promotes Absorption and/or Bioavailability of Compounds of Bio-Medical and Nutritional Interest | A. M. TODD COMPANY (US) | 2010-08-05 | — | — | US | claimed |
| US-20100076080-A1 | Synthesis of Cyclohexane Derivatives Useful as Sensates in Consumer Products | THE PROCTER & GAMBLE COMPANY | 2010-03-25 | — | — | US | claimed |
| US-5298238-A | Carriers with peppermint oil and limonene, cineole, ocimene, terpinene, terpinolene and alcohols or esters | WARNER-LAMBERT COMPANY (US) | 1994-03-29 | — | — | US | claimed |
| WO-1993008792-A1 | LIQUID ORAL COMPOSITIONS COMPRISING DETERPENATED AND FRACTIONATED FLAVOR OILS | WARNER-LAMBERT COMPANY (US) | 1993-05-13 | — | — | WO | claimed |
| US-3960970-A | MESITYL OXIDE, POTASSIUM HYDROXIDE | BASF AKTIENGESELLSCHAFT (DT) | 1976-06-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240358611-A1 | COMPOSITIONS | AZI2, NISCH, CIP2A | TRPM8 168/4885TRPA1 17/4885EPHX1 2269/4885 |
| US-12635710-B2 | Methods of using formaldehyde-free antimicrobial compositions in animal by-product compositions | FABP2, FABP1, VIP | TRPM8 4666/4885TRPA1 4347/4885EPHX1 3721/4885 |
| US-20100076080-A1 | Synthesis of Cyclohexane Derivatives Useful as Sensates in Consumer Products | NISCH, TRPM4, TRPM8 | TRPM8 3/4885TRPA1 10/4885EPHX1 528/4885 |
| US-20250325463-A1 | COMPOSITIONS (III) | NISCH, TAS1R3, TAS2R3 | TRPM8 171/4885TRPA1 4/4885EPHX1 3052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.