Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825330 | 0.90 | KDM4E (0.41) | HRH4HRH3CHEK2MCHR1 | |
| SCHEMBL2825178 | 0.90 | CHEK2 (0.41) | HRH4HRH3CHEK2MCHR1HTR6 | |
| SCHEMBL2829017 | 0.85 | PTGS2 (0.43) | NR1H2PTGS2PTGS1DPP4DPP7 | |
| SCHEMBL2822428 | 0.85 | GPR119 (0.36) | NR1H2TRPV1PTGS2PTGS1 | |
| SCHEMBL2821527 | 0.85 | PTGS2 (0.45) | NR1H2PTGS2PTGS1DPP4DPP7 | |
| SCHEMBL2826443 | 0.84 | NR1H2 (0.35) | NR1H2PTGS2PTGS1DPP4DPP7 | |
| SCHEMBL2820848 | 0.82 | HTR2B (0.41) | HRH4HRH3NR1H2TRPV1MCHR1 | |
| SCHEMBL2821151 | 0.82 | KIF18A (0.38) | NR1H2PTGS2 | |
| SCHEMBL2822519 | 0.80 | PTGS2 (0.34) | NR1H2PTGS2PTGS1DPP4DPP7 | |
| SCHEMBL2825542 | 0.79 | KIF18A (0.35) | NR1H2MCHR1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |