Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.43 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2821527 | 0.99 | PTGS2 (0.45) | PTGS2MAT2ANR1H2THRBDPP4 | |
| SCHEMBL2821151 | 0.90 | KIF18A (0.38) | PTGS2NR1H2KIF18A | |
| SCHEMBL2822519 | 0.90 | PTGS2 (0.34) | PTGS2MAT2ANR1H2THRBDPP4 | |
| SCHEMBL2822428 | 0.89 | GPR119 (0.36) | PTGS2NR1H2PTGS1 | |
| SCHEMBL2821184 | 0.88 | SMN1; SMN2 (0.37) | DPP4 | |
| SCHEMBL2824028 | 0.88 | FABP3 (0.43) | NR1H2 | |
| SCHEMBL2825467 | 0.87 | KDM4E (0.38) | — | |
| SCHEMBL2822062 | 0.87 | KDM4E (0.38) | — | |
| SCHEMBL2825677 | 0.87 | FABP3 (0.45) | MAT2A | |
| SCHEMBL2821880 | 0.87 | FABP3 (0.45) | MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |