Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828042 | 0.92 | MAPT (0.37) | ALDH1A1MEN1KMT2AMCHR1PDE4B | |
| SCHEMBL2828013 | 0.90 | ALDH1A1 (0.36) | ALDH1A1MCHR1 | |
| SCHEMBL2821151 | 0.90 | KIF18A (0.38) | KIF18APTGS2NR1H2 | |
| SCHEMBL2829017 | 0.87 | PTGS2 (0.43) | KIF18APTGS2NR1H2MAT2A | |
| SCHEMBL2821527 | 0.86 | PTGS2 (0.45) | KIF18APTGS2NR1H2MAT2A | |
| SCHEMBL2825540 | 0.84 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2APTGS2MCHR1 | |
| SCHEMBL2822519 | 0.83 | PTGS2 (0.34) | KIF18APTGS2NR1H2MAT2A | |
| SCHEMBL2822428 | 0.82 | GPR119 (0.36) | PTGS2NR1H2GPR6 | |
| SCHEMBL2824028 | 0.80 | FABP3 (0.43) | ALDH1A1MEN1KMT2ANR1H2 | |
| SCHEMBL2826443 | 0.79 | NR1H2 (0.35) | PTGS2NR1H2GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |