Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.49 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL9474810 | 0.84 | TRPM8 (0.53) | TRPM8TRPA1EPHX1CYP19A1 | |
| Demannose SCHEMBL28209682 | 0.83 | TRPM8 (0.57) | TRPM8TRPA1EPHX1LMNACYP19A1 | |
| Menthol SCHEMBL4177829 | 0.82 | TRPM8 (0.60) | TRPM8TRPA1EPHX1MAPTLMNA | |
| SCHEMBL9645931 | 0.79 | EPHX1 (0.44) | EPHX1MAPTLMNACYP19A1KDM4E | |
| SCHEMBL419463 | 0.76 | MPI (0.37) | ALDH1A1 | |
| SCHEMBL624112 | 0.76 | MPI (0.37) | ALDH1A1 | |
| Menthol SCHEMBL9645915 | 0.76 | TRPM8 (0.48) | TRPM8TRPA1EPHX1CYP19A1 | |
| Menthol SCHEMBL1664660 | 0.75 | TRPM8 (0.81) | TRPM8TRPA1EPHX1LMNAALDH1A1 | |
| Bicarbonate SCHEMBL8384988 | 0.75 | MPI (0.36) | ALDH1A1 | |
| Bicarbonate SCHEMBL8384375 | 0.75 | MPI (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5139034-A | Mixture of tobacco filler and menthyloxy carbonylglucose compounds | PHILIP MORRIS INCORPORATED (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0486212-A2 | Smoking compositions containing a menthol-release additive | Philip Morris Products Inc. (US) | 1992-05-20 | — | — | EP | disclosed |