SCHEMBL28211358

SCHEMBL28211358

CS(=O)(=O)c1ccc(Cl)c(N=O)c1

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.51
ALDH1A1 P00352 2/20 0.47
MAPT P10636 1/20 0.47
PTGS2 P35354 6/20 0.41
GLA P06280 1/20 0.41
NPC1 O15118 2/20 0.40
RAB9A P51151 1/20 0.40
G6PD P11413 1/20 0.38
IDE P14735 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21926583 0.82 ALDH1A1 (0.37) LMNAALDH1A1MAPTPTGS2
SCHEMBL28202109 0.81 GAA (0.40) ALDH1A1MAPTNPC1RAB9A
SCHEMBL27903840 0.78 PTGS2 (0.40) LMNAALDH1A1PTGS2G6PDIDE
SCHEMBL755309 0.77 LMNA (0.60) LMNAALDH1A1MAPTPTGS2GLA
SCHEMBL14146435 0.77 PTGS2 (0.43) PTGS2G6PDIDESMN1; SMN2
SCHEMBL13657209 0.77 ENPP2 (0.47) LMNAALDH1A1MAPTG6PDIDE
SCHEMBL28841252 0.75 LMNA (0.46) LMNAALDH1A1MAPTRAB9AG6PD
SCHEMBL1134252 0.74 BRD4 (0.34) LMNAALDH1A1MAPTPTGS2G6PD
SCHEMBL12638410 0.74 PTGS2 (0.58) LMNAALDH1A1MAPTPTGS2GLA
SCHEMBL5733156 0.74 LMNA (0.56) LMNAALDH1A1MAPTPTGS2GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105837528-B Preparation method of 2- (methylsulfonyl) -10H-phenothiazine 大连理工大学 2018-04-27 CN disclosed