Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28214573 | 0.81 | PSMD14 (0.39) | PIM1PIM3PIM2KDM4ECCNE2 | |
| SCHEMBL18418498 | 0.80 | PSMD14 (0.41) | PIM1TDO2PSMD14KDRFLT3 | |
| SCHEMBL20846334 | 0.80 | PIM1 (0.56) | PIM1PIM3PIM2CCNE2CCNE1 | |
| SCHEMBL28215217 | 0.80 | TDO2 (0.42) | PIM1PIM3PIM2TDO2PSMD14 | |
| SCHEMBL22510135 | 0.78 | PSMD14 (0.48) | KDM4ETDO2PSMD14L3MBTL1GRM4 | |
| SCHEMBL28214569 | 0.78 | GRM4 (0.46) | PIM1CDK2TDO2PSMD14KDR | |
| SCHEMBL28215253 | 0.77 | NR4A2 (0.56) | PIM1CDK2TDO2PSMD14KDR | |
| SCHEMBL28215207 | 0.76 | MPL (0.42) | PIM1CDK2TDO2PSMD14KDR | |
| SCHEMBL17179382 | 0.75 | IMPDH2 (0.49) | PSMD14KDRFLT3GSK3BJAK2 | |
| SCHEMBL857182 | 0.73 | TGFBR1 (0.57) | PIM1KDM4ECCNE1CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026094-A | Substituted 4-azaindoles and their use as modulators of the G L UN2B receptor | 詹森药业有限公司 | 2018-05-11 | — | — | CN | claimed |
| CN-108026094-A | Substituted 4-azaindoles and their use as modulators of the G L UN2B receptor | 詹森药业有限公司 | 2018-05-11 | — | — | CN | disclosed |